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KMID : 0604520230490020097
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Journal of the Society of Cosmetic Scientists of Korea
2023 Volume.49 No. 2 p.97 ~ p.106
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A Study on the High Content Ceramide Stabilization Formulation with Cyclodextrin
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Kim Ye-Ji
Han Sang-Woo
Lee So-Min
Cha Byung-Sun
Heo Hyo-Jin
Sofia Brito
Lei Lei
Lee Sang-Hun
Chun You-Yeon
Jo Ha-Hyeon
Kim Hyung-Mook
Kwak Byeong-Mun
Bin Bum-Ho
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Abstract
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In this study, we would like to study the stabilization of the high content of ceramide formulation by containing cyclodextrin. Ceramide, which constitutes the intercellular lipid, a human skin barrier, is a very important ingredient in moisturizing maintenance by protecting moisture in the skin and strengthening the skin barrier. However, since ceramide is poorly soluble, even if it is included in the cosmetic formulation, it has a problem that it is slowly gelled or crystallized and deposited over time, making it difficult to containing a high amount of ceramide. Cyclodextrin is a cyclic oligosaccharide connected with glucose molecules and has a cylindrical structure with hydrophilic outer surface and hydrophobic inner surface, which is known to improve the physicochemical properties of drugs such as improving solubility and absorption of poorly soluble drugs. We demonstrated the stability of the formulation containing high amount of ceramide by measuring hardness and observing emulsion drops with polarized microscope. This study also demonstrated that the high-content ceramide formulation containing cyclodextrin has the effect of preventing gelation or crystallization of ceramide, thus having excellent environmental conditions stability and skin moisturization.
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KEYWORD
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cyclodextrin, ceramide, skin barrier, moisturizing, emulsion
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